The year is 2021. Chicago has been sealed off from the rest of the Illinois to contain the outbreak of a deadly virus. Man-made, the virus was designed to target females and killed 99% of those who were infected. The women who survived were bathed in the plague and began to change. Some of those women developed superhuman abilities, incredible strength, mental control of others, supernatural control of the elements, and more. In the aftermath, two groups of gifted women banded together. One group called themselves the Sorority of Sin and sought to enslave the men who were trapped within the city. Another group, Sisterhood for the Protection of Peace, swore to protect the freedom of the city's inhabitants.